Translating colorectal cancer prevention through the guanylyl cyclase C signaling axis
نویسندگان
چکیده
منابع مشابه
Guanylyl cyclase C signaling axis and colon cancer prevention
Colorectal cancer (CRC) is a major cause of cancer-related mortality and morbidity worldwide. While improved treatments have enhanced overall patient outcome, disease burden encompassing quality of life, cost of care, and patient survival has seen little benefit. Consequently, additional advances in CRC treatments remain important, with an emphasis on preventative measures. Guanylyl cyclase C (...
متن کاملGuanylyl Cyclase C Hormone Axis at the Intersection of Obesity and Colorectal Cancer.
Obesity has emerged as a principal cause of mortality worldwide, reflecting comorbidities including cancer risk, particularly in colorectum. Although this relationship is established epidemiologically, molecular mechanisms linking colorectal cancer and obesity continue to be refined. Guanylyl cyclase C (GUCY2C), a membrane-bound guanylyl cyclase expressed in intestinal epithelial cells, binds t...
متن کاملSignaling via guanylyl cyclase C: cGMP, Src and p21
Background Guanylyl cyclase C (GC-C) is a receptor expressed in intestinal epithelial cells and activation of GCC by its ligands elevates intracellular cGMP which results in an inhibition of cell proliferation [1]. Multiple regulatory mechanisms operate in GC-C to modulate its activity, and include ligand binding to the extracellular domain, ATP binding to the kinase homology domain and additio...
متن کاملGuanylyl cyclase C messenger RNA is a biomarker for recurrent stage II colorectal cancer.
BACKGROUND Patients with stage II colorectal cancer and no histologic evidence of lymph node invasion develop recurrent disease, presumably because of undetected micrometastases. Guanylyl cyclase C is expressed by intestinal and colorectal cancer cells but not by extraintestinal tissues or tumors. OBJECTIVE To examine the expression of guanylyl cyclase C messenger RNA (mRNA) in lymph nodes of...
متن کاملExisulind and guanylyl cyclase C induce distinct antineoplastic signaling mechanisms in human colon cancer cells.
The nonsteroidal anti-inflammatory drug sulindac is metabolized to sulindac sulfone (exisulind), an antineoplastic agent that inhibits growth and induces apoptosis in solid tumors. In colon cancer cells, the antineoplastic effects of exisulind have been attributed, in part, to induction of cyclic guanosine 3',5'-monophosphate (cGMP) signaling through inhibition of cGMP-specific phosphodiesteras...
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ژورنال
عنوان ژورنال: Expert Review of Clinical Pharmacology
سال: 2013
ISSN: 1751-2433,1751-2441
DOI: 10.1586/17512433.2013.827406